Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z.
نویسندگان
چکیده
Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.
منابع مشابه
Salmonella genomic island 1 (SGI1), variant SGI1-I, and new variant SGI1-O in proteus mirabilis clinical and food isolates from China.
Salmonella genomic island 1 (SGI1) and variants (SGI1-I and the new variant SGI1-O) were mapped in five strains of Proteus mirabilis isolated from humans and food in China. Sequencing showed that SGI1 and variants were integrated at the 3' end of the chromosomal thdF gene as previously described for Salmonella strains.
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Sir, The 43 kb Salmonella genomic island 1 (SGI1) is a Salmonelladerived site-specific integrative mobilizable element that was initially characterized in multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium DT104 (where DT stands for definitive phage type) strains. SGI1 is integrated into the last 18 bp of the chromosomal trmE gene (also called thdF). SGI1 has been shown to be mob...
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25 26 27 Salmonella genomic island 1 (SGI1) and variants (SGI1-I and the new variant SGI128 O) were mapped in five strains of Proteus mirabilis isolated from humans and food 29 in China. Sequencing showed SGI1 and variants were integrated at the 3’-end of the 30 chromosomal thdF gene as previously described in Salmonella strains. 31
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Salmonella genomic island 1 (SGI1) is a multidrug resistance integrative mobilizable element that harbors a great diversity of antimicrobial resistance gene clusters described in numerous Salmonella enterica serovars and also in Proteus mirabilis. A serious threat to public health was revealed in the recent description in P. mirabilis of a SGI1-derivative multidrug resistance island named PGI1 ...
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References 1 Boyd D, Peters GA, Cloeckaert A et al. Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J Bacteriol 2001; 183: 5725–32. 2 Ahmed AM, Hussein AI, Shimamoto T. Proteus mirabilis clinical isolate harbouring a new vari...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 10 شماره
صفحات -
تاریخ انتشار 2015